Project “CanBioSe - Novel 1D photonic metal oxide nanostructures for early stage cancer detection.”

Project coordinator:

            LATVIJAS UNIVERSITATE/ UNIVERSITY OF LATVIA/ Latvia

Partners:

            VILNIAUS UNIVERSITETAS/ Lithuania

            ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER/ France

            UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU/ Poland

            FONDAZIONE BRUNO KESSLER/ Italy

            EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE AS/ Estonia

            BIOSENSOR S.R.L./ Italy

            NANOPHARMA AS/ Czech Republic

            NANO PRIME SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA/ Poland

            MATERIALS RESEARCH CENTER/ Ukraine

            Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus/ Belarus

      

CanBioSe – A project that will help with early cancer detection

The project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve one of the important health challenges in EU society. The CanBioSe project is targeted to strengthen international and intersectoral collaboration, sharing new ideas, knowledge transfer from research to market, and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cell detection.

More than just research:

The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialization. The provided research and management training to experienced researchers and early stage researchers will be quite beneficial. It will strengthen their personal skills and CVs via the new scientific papers and conference theses and strengthen a development of EU research human resources. We foresee a long lasting collaboration between the partners, based on co-supervising students and the preparation of novel collaborative project proposals. Also foreseen is a dissemination of the project results to the scientific society and wide auditories.

Scientific work will include:

One dimensional (1D) polimer nanofibers will be deposited by an electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.

 

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 778157.